Tag Archives: laboratory

Von Willebrand Disease: The 4 minute overview [with images]

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Von Willebrand Disease (VWD) is a genetic disorder caused by missing or defective von Willebrand factor (VWF), a clotting protein. VWF binds factor VIII, a key clotting protein, and platelets in blood vessel walls, which help form a platelet plug during the clotting process. [1] History of the disease  The first written piece describing this inherited   …Continue Reading

3 tips that could change your coagulation laboratory results

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Laboratories use normal reference ranges (NRRs) to identify whether a test result is within the normal range or outside this range (and to thus identify an abnormal result). The relative false positive to true positive rate increases substantially for rare disorders and is a particular problem with congenital disorders such as protein C, protein S,   …Continue Reading

Making Sense of Mixing Studies

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A physician may order mixing studies when a patient’s prothrombin time (PT), activated partial thromboplastin time, (aPTT) or both PT and aPTT are prolonged outside the upper limit of the laboratory’s established normal range. Determining the cause of the prolongation It is important to determine if the cause of the prolongation is due to a   …Continue Reading