Bleeding Disorders

Factor Sensitivities – What’s the value, anyway? [Pun intended]

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Currently the global test used to detect intrinsic factor deficiencies in patients with bleeding is the activated partial thromboplastin time (APTT). The APTT reagent used should be sensitive to a reduction in coagulation factors such as FVIII and FIX that are commonly associated with bleeding. Literature states that it is desirable to have APTT systems   …Continue Reading

Von Willebrand Disease: The 4 minute overview [with images]

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Von Willebrand Disease (VWD) is a genetic disorder caused by missing or defective von Willebrand factor (VWF), a clotting protein. VWF binds factor VIII, a key clotting protein, and platelets in blood vessel walls, which help form a platelet plug during the clotting process. [1] History of the disease  The first written piece describing this inherited   …Continue Reading